What are the eight principles of chronic nephritis treatment

Chronic nephritis is a kidney disease that requires long-term treatment. It is not a simple medication to recover. So what are the principles of treatment for chronic nephritis? Let's take a look at what the experts say.

Chronic glomerulonephritis referred to as chronic nephritis refers to proteinuria, hematuria, hypertension, edema as the basic clinical manifestations, the onset of the disease are different, the condition is protracted, the lesion progresses slowly, there may be varying degrees of renal dysfunction, with kidney Deterioration of function and a group of glomerulopathy that will eventually develop into chronic renal failure. Due to the different pathological types and stages of the disease in this group, the main clinical manifestations may vary. The disease is diversified.

The principle of treatment of chronic nephritis

First, The bed has a good rest:

acute nephritis bed rest is very important. In bed can increase renal blood flow, can improve abnormal urine changes. Prevent and reduce complications and prevent reinfection. When the edema subsides, the blood pressure drops, and the urine abnormalities abate, proper amount of walking can be done, and mild activities can be gradually increased to prevent a sudden increase in activity.

Second, diet and water:

Moisture intake in terms of urine output, edema, hypertension and the presence or absence of heart failure, to limit the moisture in the acute phase is appropriate, but should not be excessive to prevent a sudden lack of blood volume. The salt intake should be limited to about 2 g/d when there is marked edema and high blood pressure. Protein intake, blood urea nitrogen below 14.28mmol/L (40mg/dl), protein may not limit: 14.28 ~ 21.42mmol / L (40 ~ 60mg/dl) can be limited to 1.0g per kilogram of body weight; 21.42mmol /L (60mg/dl) or more, then 0.5g/kg body weight per day, protein is preferred for high quality protein, such as eggs, milk, lean meat and so on. However, it is generally advisable to enter a low-protein, high-sugar diet until the onset of diuresis. After the symptoms are basically relieved, the routine diet is resumed.

Third, anti-infective treatment:

In the acute phase of nephritis in the case of infected lesions to give adequate anti-infective treatment, no infection, generally do not have to be appropriate. The use of antibiotics to prevent the recurrence of this disease is often ineffective.

Fourth, the treatment of edema:

mild edema without treatment, salt and rest can disappear after rest. Obvious edema can be used furosemide, hydrochlorothiazide, spironolactone or triamterene combined application, generally intermittent application is better than continuous application.

Fifth, the treatment of hypertension and heart failure: 

patients with hypertension need conventional treatment of hypertension. If the blood pressure is significantly increased, it is not appropriate to make the blood pressure drop suddenly, or even to normal, in order to prevent a sudden decrease in renal blood flow, affecting or aggravating renal insufficiency. The treatment of heart failure, due to the presence of high blood volume in the early stages of acute nephritis, the effect of digitalis application is not necessarily ideal, the treatment should focus on the removal of water, sodium phlegm slip, reduce blood volume.

Sixth,Anticoagulation therapy:

According to the pathogenesis, coagulation in the glomerulus is an important pathological change, mainly cellulose deposition and platelet aggregation. Therefore, in the treatment, anticoagulant therapy may be used, which will contribute to the remission of nephritis. Specific methods: 1 heparin 0.8 ~ 1.0mg/kg body weight by adding 5% glucose 250ml, intravenous infusion, once daily, 10 to 14 times for a course of treatment, interval 3 to 5 days before the next course of treatment, a total of 2 ~ 3 courses. 2 Dipyridamole 50~100mg 3 times daily. 3 Salvia 20 ~ 30 grams of intravenous infusion, can also use urokinase 2 ~ 60,000 u add 5% glucose 250ml intravenous infusion, once a day, 10 days for a course of treatment, according to the condition of 2 to 3 courses. However, it should be noted that heparin and urokinase can not be applied simultaneously.

Seventh,Antioxidant applications:

Superoxide dismutase (SOD), selenium-containing glutathione peroxidase and vitamin E can be used. 1 Superoxide dismutase can convert O- into H2O2,2 containing selenium glutathione peroxidase (SeGsHPx), which reduces H2O2 to H2O. 3 Vitamin E is a lipid-soluble scavenger on plasma and erythrocyte membranes in the body. Vitamin E and coenzyme Q10 can scavenge free radicals, block the chain reaction of free radical-triggered lipid peroxidation, protect kidney cells, and reduce the inflammatory process in the kidney.

Eight, Chinese medicine treatment

Cold type: acute onset, chills, fever, cough, head edema, oliguria, high blood pressure, thin white tongue coating, pulse floating tight. Governance is to spread the lungs and water. Prescriptions: Ephedra, almonds, dried wolfberry, mulberry, wolfberry, psyllium, winter melon, ginger, thirst plus gypsum.

Wind-heat type: fever is not chilly, sore throat, mild swelling of the face, thin yellow tongue coating, urine short-skin astringent, visible gross hematuria. The rule is to clear the wind and heat, cool blood detoxification. Prescriptions: Forsythia, silver flower, mulberry leaf, chrysanthemum, dandelion, mint, gypsum, pollen, red peony, fresh chine.

Hot and humid type: There may be fever, dry lips, dry mouth, yellow tongue coating, slippery pulse, little red urine, head or body edema. Treatment is heat and dampness or heat detoxification, prescription: Atractylodes, Phellodendron, Fang has been, swine fever, cicada skin, pokeweed, abdomen skin, wood pass, Alisma, red bean, pepper head.

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