Problem:
1, IgA nephropathy stages and symptoms of what is the stage?
2, why IgA nephropathy is difficult to treat?
3, Chinese medicine in the treatment of IgA have any contribution?
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| from google |
According to the process of nephron pathological changes, IgA nephropathy can be divided into five phases:
IgA nephropathy a
There was no abnormality other than a mild increase in mesangium.
At this point only intermittent urine occult blood, usually not be found.
IgA nephropathy two
Mesangial area began to appear focal proliferation and sclerosis phenomenon, but still no other abnormalities.
At this point still only intermittent urine occult blood, which is slightly higher than the frequency of a period, still difficult to find.
IgA nephropathy three
Mesangial proliferation and widening began to diffuse, and glomerular crescent began emerging, tubular, interstitial began to appear focal edema, and cell infiltration.
This stage is a watershed, urinary occult blood began to persist, some patients will also appear urine protein and high blood pressure and other symptoms, diagnosed more at this stage.
IgA nephropathy four
Mesangial proliferation and sclerosis have been severe diffuse, has begun to appear glomerular sclerosis, and renal tubular atrophy and interstitial infiltration is also aggravating, the glomerular crescent has been close to 50%, kidney damage has been very serious.
This stage has been renal insufficiency, in addition to urinary occult blood, urine protein, high blood pressure and other symptoms are more serious, and the impact of renal insufficiency, such as anemia, electrolyte imbalance, bone disease, heart failure, etc. .
IgA nephropathy five
Five and four similar situation, but more serious, glomerular crescent has more than 50%, is developing to the terminal.
This stage of treatment the most difficult, because renal function has been severely reduced, some patients have reached the stage of uremia, so the main conservative treatment.
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| from google |
Difficulties in the treatment of IgA nephropathy not only lie in the mesangial area IgA immune complexes difficult to clean up, but also that mesangial area proliferation and sclerosis will lead to a large number of glomerular sclerotic necrosis.
More seriously, this also led to the tubular and interstitial atrophy and infiltration, so that a sharp decline in renal function, about 10% -20% of patients within ten years into the stage of chronic renal failure.
IgA nephropathy is still the main conventional treatment, that is, for urinary occult blood, urine protein, high blood pressure and other symptoms of treatment.
Treatment is relatively poor, mainly dependent on the maintenance of compensatory function of the residual nephron.
IgA nephropathy new treatment ideas
In addition to symptomatic treatment of Western medicine, you can also use traditional Chinese medicine conditioning treatment.
Chinese medicine treatment of IgA nephropathy, the main breakthrough point is to alleviate renal cell sclerosis.
We know that both the glomerular sclerosis and tubular atrophy, the impact on renal function are very large, and this sclerosis is irreversible. If you can delay the rate of hardening, IgA nephropathy will greatly reduce the rate of progress.
Chinese medicine to delay renal cell sclerosis is to improve kidney microcirculation to solve the status of renal cell ischemia and hypoxia.
Because both the deposition of IgA and mesangial hyperplasia, can lead to poor microcirculation of the kidney, for itself is the capillary group of the kidneys, will lead to a large number of renal cells in the hypoxic-ischemic state, which is also sclerosis and atrophy The main reason.
Therefore, the use of traditional Chinese medicine to improve renal microcirculation, combined with Western symptomatic treatment, in order to achieve better results.
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