Causes of interstitial nephritis and what are the symptoms

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Interstitial nephritis is a nephrotic syndrome that causes tubular damage. Depending on the degree of renal tubular injury, the severity of symptoms is different. What causes the interstitial nephritis? What are the symptoms?

What are the causes of interstitial nephritis What is the cause of interstitial nephritis What are the symptoms of interstitial nephritis

The so-called interstitial nephritis, also known as tubulointerstitial nephritis, is caused by a variety of reasons, tubulointerstitial acute and chronic damage of clinicopathological syndrome. Clinical often divided into acute interstitial nephritis, chronic interstitial nephritis. Acute interstitial nephritis caused by a variety of reasons for a short period of occurrence of interstitial inflammatory cell infiltration, interstitial edema, tubule injury with varying degrees of renal dysfunction characterized by clinical manifestations can be light and heavy.

What is the cause of interstitial nephritis?

1, infection: Here can lead to infection mainly bacteria, fungi and viruses and other pathogenic microorganisms.

2, systemic diseases: such as systemic lupus erythematosus, Sjogren's syndrome, sarcoidosis, primary cryoglobulinemia. Hematological disorders such as multiple myeloma, paroxysmal hemoglobinuria, lymphoproliferative disorders, sickle cell disease, and the like.

3, drug-induced disease: may be cyclosporine, aminoglycoside antibiotics, amphotericin B, analgesics, non-steroidal anti-inflammatory drugs, cisplatin and other long-term application related.

4, heavy metal salts: may be related to such as cadmium, lithium, aluminum, gold, beryllium and other long-term exposure.

5, chemical poisons or biological toxins: such as carbon tetrachloride, tetrachlorethylene, methanol, ethylene glycol, coal phenol, nitrosourea or snake venom, fish poison, bee venom, muscaria poisoning history.

6, metabolic diseases: such as cystine disease, hypokalemic nephropathy, uric acid nephropathy, diabetic nephropathy and amyloidosis history.

What are the symptoms of interstitial nephritis?

1, hypertension, is one of the symptoms of interstitial nephritis, sustained over the moderate level of hypertension, but also have dizziness or headache, retinoscopy, papilledema, fundus bleeding. This situation can be maintained for several years or even decades, and eventually the performance of chronic renal failure due to progressive deterioration of renal function.

2, edema, many patients with interstitial nephritis will appear edema, mainly in the lower extremities more common. Eyelid and facial edema can also be acute attack.


3, anemia, early symptoms of interstitial nephritis, early edema in interstitial nephritis obvious, there may be mild anemia. Late renal failure, decreased erythropoietin, can occur moderate to severe anemia, fatigue, fatigue, loss of appetite.

4, abnormal urine, many patients will appear symptoms of abnormal urine, urine such as thick tea or wash water, urine cloudy with foam, nocturia in the bubble.

5, the majority of patients in the pathogenesis of the process, there will be backache or pain, fatigue, loss of appetite, looking no or dark embolism, prone to respiratory tract, urinary tract and other parts of the infection.

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