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Hypertension and kidney are both close and complicated. High blood pressure can cause kidney damage, and many kidney diseases are prone to high blood pressure. Hypertension and kidney disease affect each other, each cause and effect, and even the formation of a vicious circle.
Hypertension is a cardiovascular disease, and the kidneys are also organs made up of tiny blood vessels. Long-term hypertension also damages the small arteries of the kidneys. Hypertension causes the spasms of the renal arterioles, leading to ischemia and hypoxia of renal vessels, Small ball endothelial cells. Once damaged endothelial cells will be induced by the inflammatory cell infiltration in the blood circulation and release of pathogenic inflammatory mediators, then the local pathological changes of glomerular: glomerular basement membrane changes, filtration holes increased, the charge barrier Damage, increased renal permeability, this time there will be proteinuria.
The majority of patients with hypertension can have varying degrees of renal changes, but the occurrence of hypertensive nephropathy is a slow process of progress. The general development of essential hypertension with sustained and stable development of 5-10 years can be mild to moderate renal arteriosclerosis, which in turn damages the kidneys, occurs in the long-term hypertension is not well controlled. In mild to moderate essential hypertension, the early course of a long period of time, due to the regulation of the kidney itself does not appear structural and functional changes in the kidneys, only when the kidneys this self-regulatory dysfunction, hypertensive state Under the high sodium load and acute capacity expansion and other pathological conditions, after a certain period of time, the gradual emergence of renal tubular damage and functional damage.
The relationship between high blood pressure and the kidneys is very complex and close, and the two are mutually causal under different circumstances. Long-term high blood pressure is bound to involve the kidneys, and changes in the structure and function of the kidneys can cause high blood pressure. In both cases, elevated blood pressure and kidney damage can aggravate each other, forming a vicious cycle chain. It is precisely because of high blood pressure and renal disease are closely related, it is recommended that patients with hypertension should go to the hospital regularly to check urine and renal function. In daily life should also pay attention to whether they have edema, increased nocturia, urine and other symptoms of foam. Once found that the above symptoms may have kidney damage, the need to go to the hospital in time.
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