Uric acid is high in the body there is a substance called purine due to metabolic disorders, resulting in increased blood uric acid caused by a metabolic disease, the body's daily production and excretion of uric acid is about the same amount of formation, the third One is from the food, two thirds is the body's own synthesis, excretion pathway is one third discharged from the intestine, two thirds excreted from the kidneys.
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High uric acid is sub-period, in different stages, there will be different performance.
1, asymptomatic hyperuricemia: blood tests found that serum uric acid concentration increased, but no arthritis, hyperuricemia, stone or kidney stones and other clinical symptoms. Unless during this test, generally not easy to detect. Asymptomatic hyperuricemia. Seria can persist for 10 to 20 years, and some can be lifelong does not appear high uric acid. In general, the higher the level of serum uric acid, the greater the risk of high uric acid.
2, acute hyperuricemia arthritis: Four seasons can be disease, with the most spring, autumn. Local joint injury, overeating, fatigue, wet and cold, some drugs, infections and surgery can induce acute attack. These factors can make the already saturated state of uric acid to form acicular crystals deposited in synovial fluid, the body of white blood cells in the body is regarded as alien and swallowed, is released after the release of inflammatory cytokines, causing acute attacks.
3, gouty arthritis: general attack site for the thumb joints, ankles, knees and so on. Some gout in patients with long-term gout in the fingers and joints, and even auricle with soft tissue parts. Acute gout attack sites appear red, swollen, hot, severe pain, usually more in the midnight attack, can make people awake from sleep. Early gout, seizures more common in lower extremities. Gout can also occur with kidney damage.
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