Mentioned kidney treatment, people may first think of hormones, which is an important drug to eliminate urinary protein, it is time-tested.
But the problem is, some patients will appear "hormone resistance", what is the reason?
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In the treatment of nephropathy, we often say that the hormone is actually glucocorticoid, which is secreted by the adrenal hormones, but due to kidney damage in patients with kidney disease, resulting in their own lack of secretion, so need to be supplemented by drugs.
The main role of hormones is to regulate sugar, fat, protein synthesis and metabolism, and has a strong anti-inflammatory effect.
In the treatment of kidney disease, the real role of hormones is anti-inflammatory.
We know that most types of nephropathy are caused by inflammatory reactions. The persistent inflammatory reaction in the kidneys will lead to the damage of renal cells and the leakage of proteins and other substances, thus forming the urine protein, occult blood and other symptoms. Therefore, the treatment of early nephropathy, The point is to control the inflammatory response.
A lot of kidney disease patients with urinary protein after the use of hormones on the negative, because inflammation is suppressed live, renal cells are no longer sustained death, coupled with the kidney itself compensatory strong, so filtration was restored, so urinary protein Will disappear ,But by no means does this mean that the cause of the inflammatory reaction is also eliminated by the hormones, not to mention that the dead kidney cells are revived.
Why does it produce "hormone dependence"?
Some nephrotic patients said that after the reduction or withdrawal of hormones, urinary protein soon appeared again, what happened?
This is actually a "rebound phenomenon", referring to reduction too fast or sudden withdrawal, resulting in reversal of the condition.
We know that glucocorticoids itself is secreted by the adrenal glands. Our long-term use of hormonal drugs causes misunderstandings in the body, thus "ordering" the adrenal gland to reduce the secretion of hormones. When patients who are unknowingly reduce their dosage, the amount of adrenal hormone secretion Did not increase, leading to rapid decline in plasma concentration, there is no power to continue to suppress the inflammatory response, so the recurrence of kidney disease.
The response is to resume the dose again and to reduce the rate of drug reductions.
Do not stop medicine!
Correct understanding of hormones
Use hormone treatment of kidney disease, we must have a correct understanding of hormones:
① hormones to eliminate urinary protein through anti-inflammatory, and for those high blood pressure, diabetes or tubular proteinuria caused by urinary albumin, hormone effect is not good;
② hormone-dependent causes of their own lack of secretion, so slow down the speed of medicine, but also find ways to improve their own secretory capacity;
Although hormones will cause full-moon face, buffalo back and other body changes, but the withdrawal of one year after the basic side effects will disappear, only a very small number of repeated many people difficult to recover;
④ Most doctors have their own unique hormone reduction program, please follow the doctor's advice. If you change the attending physician, please be sure to inform before the reduction program.
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